Pharmacogenetics of antidepressant response
نویسندگان
چکیده
منابع مشابه
Pharmacogenetics of antidepressant response: A polygenic approach.
BACKGROUND Major depressive disorder (MDD) has a high personal and socio-economic burden and >60% of patients fail to achieve remission with the first antidepressant. The biological mechanisms behind antidepressant response are only partially known but genetic factors play a relevant role. A combined predictor across genetic variants may be useful to investigate this complex trait. METHODS Po...
متن کاملPharmacogenetics of antidepressant medication intolerance.
OBJECTIVE The authors sought to identify genetic markers for antidepressant medication intolerance. Genetic variation in drug metabolizing enzymes such as cytochrome P450 2D6 (CYP2D6) has been postulated to underlie antidepressant intolerance (pharmacokinetic effect). However, variation in genes encoding serotonin receptors could also explain antidepressant side effects (pharmacodynamic effect)...
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Pharmacological treatment of depressive disorders is characterized by poor predictability of individual response. In recent years, the increasing evidence has demonstrated that genetic factors play a critical role in determining the differences in treatment outcome to antidepressant drugs. A number of pharmacogenetic studies on antidepressant drugs has been conducted, and genetic variations at ...
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ژورنال
عنوان ژورنال: Journal of Psychiatry & Neuroscience
سال: 2011
ISSN: 1180-4882
DOI: 10.1503/jpn.100059